Crystal Structures of TbCatB and Rhodesain, Potential Chemotherapeutic Targets and Major Cysteine Proteases of Trypanosoma brucei

BACKGROUND: Trypanosoma brucei is the etiological agent of Human African Trypanosomiasis, an endemic parasitic disease of sub-Saharan Africa. TbCatB and rhodesain are the sole Clan CA papain-like cysteine proteases produced by the parasite during infection of the mammalian host and are implicated in...

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Autores principales: Kerr, Iain D., Wu, Peng, Marion-Tsukamaki, Rachael, Mackey, Zachary B., Brinen, Linda S.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2010
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2882330/
https://ncbi.nlm.nih.gov/pubmed/20544024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0000701
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