Rearrangements of the retinoic acid receptor alpha and promyelocytic leukemia zinc finger genes resulting from t(11;17)(q23;q21) in a patient with acute promyelocytic leukemia.

Cytogenetic study of a patient with acute promyelocytic leukemia (APL) showed an unusual karyotype 46,xy,t(11;17) (q23;21) without apparent rearrangement of chromosome 15. Molecular studies showed rearrangements of the retinoic acid receptor alpha (RAR alpha) gene but no rearrangement of the promyel...

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Bibliographic Details
Published in:J Clin Invest
Main Authors: Chen, S J, Zelent, A, Tong, J H, Yu, H Q, Wang, Z Y, Derré, J, Berger, R, Waxman, S, Chen, Z
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 1993
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC288229/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8387545/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116453
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