A Phenotype–Genotype Approach to Predicting CYP450 and P-Glycoprotein Drug Interactions With the Mixed Inhibitor/Inducer Tipranavir/Ritonavir

The effects of tipranavir/ritonavir (TPV/r) on hepatic and intestinal P-glycoprotein (P-gp) and cytochrome P450 (CYP) enzyme activity were evaluated in 23 volunteers. The subjects received oral (p.o.) caffeine, warfarin + vitamin K, omeprazole, dextromethorphan, and midazolam and digoxin (p.o. and i...

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Autores principales: Dumond, JB, Vourvahis, M, Rezk, NL, Patterson, KB, Tien, H-C, White, N, Jennings, SH, Choi, SO, Li, J, Wagner, MJ, La-Beck, NM, Drulak, M, Sabo, JP, Castles, MA, MacGregor, TR, Kashuba, ADM
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2882206/
https://ncbi.nlm.nih.gov/pubmed/20147896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/clpt.2009.253
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