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Characterization of a naturally-occurring p27 mutation predisposing to multiple endocrine tumors
BACKGROUND: p27Kip1 (p27) is an important negative regulator of the cell cycle and a putative tumor suppressor. The finding that a spontaneous germline frameshift mutation in Cdkn1b (encoding p27) causes the MENX multiple endocrine neoplasia syndrome in the rat provided the first evidence that Cdkn1...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2881881/ https://ncbi.nlm.nih.gov/pubmed/20492666 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-9-116 |
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