Characterization of a naturally-occurring p27 mutation predisposing to multiple endocrine tumors

BACKGROUND: p27Kip1 (p27) is an important negative regulator of the cell cycle and a putative tumor suppressor. The finding that a spontaneous germline frameshift mutation in Cdkn1b (encoding p27) causes the MENX multiple endocrine neoplasia syndrome in the rat provided the first evidence that Cdkn1...

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Bibliografske podrobnosti
Main Authors: Molatore, Sara, Kiermaier, Eva, Jung, Christian B, Lee, Misu, Pulz, Elke, Höfler, Heinz, Atkinson, Michael J, Pellegata, Natalia S
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2010
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2881881/
https://ncbi.nlm.nih.gov/pubmed/20492666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-9-116
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