CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases

Human liver CYP3A4 is an endoplasmic reticulum (ER)-anchored hemoprotein responsible for the metabolism of >50% of clinically prescribed drugs. After heterologous expression in Saccharomyces cerevisiae,it is degraded via the ubiquitin (Ub)-dependent 26S proteasomal pathway that utilizes Ubc7p/Cue...

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Main Authors: Pabarcus, Michael K., Hoe, Nicholas, Sadeghi, Sheila, Patterson, Cam, Wiertz, Emmanuel, Correia, Maria Almira
Formato: Artigo
Idioma:Inglês
Publicado: 2008
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2881844/
https://ncbi.nlm.nih.gov/pubmed/19103148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2008.12.001
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