CYP3A4-Mediated Carbamazepine (CBZ) Metabolism: Formation of a Covalent CBZ-CYP3A4 Adduct and Alteration of the Enzyme Kinetic Profile

Carbamazepine (CBZ) is a widely prescribed anticonvulsant whose use is often associated with idiosyncratic hypersensitivity. Sera of CBZ-hypersensitive patients often contain anti-CYP3A antibodies, including those to a CYP3A23 K-helix peptide that is also modified during peroxidative CYP3A4 heme-fra...

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Bibliographic Details
Main Authors: Kang, Ping, Liao, Mingxiang, Wester, Michael R., Leeder, J. Steven, Pearce, Robin E., Correia, Maria Almira
Format: Artigo
Language:Inglês
Published: 2007
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2881839/
https://ncbi.nlm.nih.gov/pubmed/18096676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.107.016501
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