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Effects of EPHX1 and CYP3A4 polymorphisms on carbamazepine metabolism in epileptic patients
BACKGROUND: The aim of this study was to investigate the effect of two genetic polymorphisms in the coding regions (exon 3 and exon 4) of the EPHX1 gene, ie, 337T>C and 416A>G, respectively, on the metabolism of carbamazepine (CBZ) 10,11-epoxide (the active metabolite of CBZ) by evaluating the...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Dove Medical Press
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4012346/ https://ncbi.nlm.nih.gov/pubmed/24817818 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/PGPM.S55548 |
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