The Fbw7/Human CDC4 Tumor Suppressor Targets Proproliferative Factor KLF5 for Ubiquitination and Degradation through Multiple Phosphodegron Motifs

The proproliferative transcription factor KLF5 plays an important role in promoting cell proliferation and tumorigenesis. KLF5 is a short-lived protein that can be rapidly degraded through the ubiquitin-proteasome pathway in cancer cells. However, the mechanisms regulating protein stability remain p...

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Detalhes bibliográficos
Main Authors: Liu, Ning, Li, Hui, Li, Shuangxi, Shen, Mingyue, Xiao, Ning, Chen, Yunfei, Wang, Yan, Wang, Weichao, Wang, Rui, Wang, Qian, Sun, Jianhua, Wang, Ping
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2881808/
https://ncbi.nlm.nih.gov/pubmed/20388706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.099440
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