Discovery of PDK1 Kinase Inhibitors with a Novel Mechanism of Action by Ultrahigh Throughput Screening

The phosphoinositide 3-kinase/AKT signaling pathway plays a key role in cancer cell growth, survival, and angiogenesis. Phosphoinositide-dependent protein kinase-1 (PDK1) acts at a focal point in this pathway immediately downstream of phosphoinositide 3-kinase and PTEN, where it phosphorylates numer...

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Hlavní autoři: Bobkova, Ekaterina V., Weber, Michael J., Xu, Zangwei, Zhang, Yan-Ling, Jung, Joon, Blume-Jensen, Peter, Northrup, Alan, Kunapuli, Priya, Andersen, Jannik N., Kariv, Ilona
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
Témata:
Enzymology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2881806/
https://ncbi.nlm.nih.gov/pubmed/20385558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.089946
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