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Protein Kinase D Controls Actin Polymerization and Cell Motility through Phosphorylation of Cortactin
We here identify protein kinase D (PKD) as an upstream regulator of the F-actin-binding protein cortactin and the Arp actin polymerization machinery. PKD phosphorylates cortactin in vitro and in vivo at serine 298 thereby generating a 14-3-3 binding motif. In vitro, a phosphorylation-deficient corta...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2881792/ https://ncbi.nlm.nih.gov/pubmed/20363754 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.093880 |
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