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Src phosphorylation of cortactin enhances actin assembly

Src kinase mediates growth factor signaling and causes oncogenic transformation, which includes dramatic changes in the actin cytoskeleton, cell shape, and motility. Cortactin was discovered as a substrate for Src. How phosphorylation of cortactin can enhance actin assembly is unknown. Here, using a...

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Autori principali: Tehrani, Shandiz, Tomasevic, Nenad, Weed, Scott, Sakowicz, Roman, Cooper, John A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2007
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1924558/
https://ncbi.nlm.nih.gov/pubmed/17606906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0701077104
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