Specific tyrosine phosphorylation sites on cortactin regulate Nck1-dependent actin polymerization in invadopodia

Invadopodia are matrix-degrading membrane protrusions in invasive carcinoma cells enriched in proteins that regulate actin polymerization. The on–off regulatory switch that initiates actin polymerization in invadopodia requires phosphorylation of tyrosine residues 421, 466, and 482 on cortactin. How...

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Autors principals: Oser, Matthew, Mader, Christopher C., Gil-Henn, Hava, Magalhaes, Marco, Bravo-Cordero, Jose Javier, Koleske, Anthony J., Condeelis, John
Format: Artigo
Idioma:Inglês
Publicat: Company of Biologists 2010
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3037016/
https://ncbi.nlm.nih.gov/pubmed/20971703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.068163
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