Modifying Apolipoprotein A-I by Malondialdehyde, but Not by an Array of Other Reactive Carbonyls, Blocks Cholesterol Efflux by the ABCA1 Pathway

Dysfunctional high density lipoprotein (HDL) is implicated in the pathogenesis of cardiovascular disease, but the underlying pathways remain poorly understood. One potential mechanism involves covalent modification by reactive carbonyls of apolipoprotein A-I (apoA-I), the major HDL protein. We there...

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Bibliographic Details
Main Authors: Shao, Baohai, Pennathur, Subramaniam, Pagani, Ioanna, Oda, Michael N., Witztum, Joseph L., Oram, John F., Heinecke, Jay W.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Lipids
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2881773/
https://ncbi.nlm.nih.gov/pubmed/20378541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.118182
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