IDH1 and IDH2 Gene Mutations Identify Novel Molecular Subsets Within De Novo Cytogenetically Normal Acute Myeloid Leukemia: A Cancer and Leukemia Group B Study

PURPOSE: To analyze the frequency and associations with prognostic markers and outcome of mutations in IDH genes encoding isocitrate dehydrogenases in adult de novo cytogenetically normal acute myeloid leukemia (CN-AML). PATIENTS AND METHODS: Diagnostic bone marrow or blood samples from 358 patients...

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Autores principales: Marcucci, Guido, Maharry, Kati, Wu, Yue-Zhong, Radmacher, Michael D., Mrózek, Krzysztof, Margeson, Dean, Holland, Kelsi B., Whitman, Susan P., Becker, Heiko, Schwind, Sebastian, Metzeler, Klaus H., Powell, Bayard L., Carter, Thomas H., Kolitz, Jonathan E., Wetzler, Meir, Carroll, Andrew J., Baer, Maria R., Caligiuri, Michael A., Larson, Richard A., Bloomfield, Clara D.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Clinical Oncology 2010
Materias:
Original Reports
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2881719/
https://ncbi.nlm.nih.gov/pubmed/20368543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2009.27.3730
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