Common variants at 30 loci contribute to polygenic dyslipidemia

Blood low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol and triglyceride levels are risk factors for cardiovascular disease. To dissect the polygenic basis of these traits, we conducted genome-wide association screens in 19,840 individuals and replication in up to...

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Autors principals: Kathiresan, Sekar, Willer, Cristen J, Peloso, Gina, Demissie, Serkalem, Musunuru, Kiran, Schadt, Eric, Lee, Kaplan, Bennett, Derrick, Li, Yun, Tanaka, Toshiko, Voight, Benjamin F, Bonnycastle, Lori L, Jackson, Anne U, Crawford, Gabriel, Surti, Aarti, Guiducci, Candace, Burtt, Noel, Parish, Sarah, Clarke, Robert, Zelenika, Diana, Kubalanza, Kari A, Morken, Mario A, Scott, Laura J, Stringham, Heather M, Galan, Pilar, Swift, Amy J, Kuusisto, Johanna, Bergman, Richard N, Sundvall, Jouko, Laakso, Markku, Ferrucci, Luigi, Scheet, Paul, Sanna, Serena, Uda, Manuela, Yang, Qiong, Lunetta, Kathryn, Dupuis, Josee, deBakker, Paul I, O’Donnell, Christopher J, Chambers, John C, Kooner, Jaspal S, Hercberg, Serge, Meneton, Pierre, Lakatta, Edward G, Scuteri, Angelo, Schlessinger, David, Tuomilehto, Jaakko, Collins, Francis S, Groop, Leif, Altshuler, David, Collins, Rory, Lathrop, G Mark, Melander, Olle, Salomaa, Veikko, Peltonen, Leena, Orho-Melander, Marju, Ordovas, Jose M, Boehnke, Michael, Abecasis, Gonçalo R, Mohlke, Karen L, Cupples, L Adrienne
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2881676/
https://ncbi.nlm.nih.gov/pubmed/19060906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.291
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