Common variants at 30 loci contribute to polygenic dyslipidemia

Blood low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol and triglyceride levels are risk factors for cardiovascular disease. To dissect the polygenic basis of these traits, we conducted genome-wide association screens in 19,840 individuals and replication in up to...

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Main Authors: Kathiresan, Sekar, Willer, Cristen J, Peloso, Gina, Demissie, Serkalem, Musunuru, Kiran, Schadt, Eric, Lee, Kaplan, Bennett, Derrick, Li, Yun, Tanaka, Toshiko, Voight, Benjamin F, Bonnycastle, Lori L, Jackson, Anne U, Crawford, Gabriel, Surti, Aarti, Guiducci, Candace, Burtt, Noel, Parish, Sarah, Clarke, Robert, Zelenika, Diana, Kubalanza, Kari A, Morken, Mario A, Scott, Laura J, Stringham, Heather M, Galan, Pilar, Swift, Amy J, Kuusisto, Johanna, Bergman, Richard N, Sundvall, Jouko, Laakso, Markku, Ferrucci, Luigi, Scheet, Paul, Sanna, Serena, Uda, Manuela, Yang, Qiong, Lunetta, Kathryn, Dupuis, Josee, deBakker, Paul I, O’Donnell, Christopher J, Chambers, John C, Kooner, Jaspal S, Hercberg, Serge, Meneton, Pierre, Lakatta, Edward G, Scuteri, Angelo, Schlessinger, David, Tuomilehto, Jaakko, Collins, Francis S, Groop, Leif, Altshuler, David, Collins, Rory, Lathrop, G Mark, Melander, Olle, Salomaa, Veikko, Peltonen, Leena, Orho-Melander, Marju, Ordovas, Jose M, Boehnke, Michael, Abecasis, Gonçalo R, Mohlke, Karen L, Cupples, L Adrienne
Format: Artigo
Jezik:Inglês
Izdano: 2008
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2881676/
https://ncbi.nlm.nih.gov/pubmed/19060906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.291
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