Common variants at 30 loci contribute to polygenic dyslipidemia

Blood low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol and triglyceride levels are risk factors for cardiovascular disease. To dissect the polygenic basis of these traits, we conducted genome-wide association screens in 19,840 individuals and replication in up to...

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Detalhes bibliográficos
Main Authors: Kathiresan, Sekar, Willer, Cristen J, Peloso, Gina, Demissie, Serkalem, Musunuru, Kiran, Schadt, Eric, Lee, Kaplan, Bennett, Derrick, Li, Yun, Tanaka, Toshiko, Voight, Benjamin F, Bonnycastle, Lori L, Jackson, Anne U, Crawford, Gabriel, Surti, Aarti, Guiducci, Candace, Burtt, Noel, Parish, Sarah, Clarke, Robert, Zelenika, Diana, Kubalanza, Kari A, Morken, Mario A, Scott, Laura J, Stringham, Heather M, Galan, Pilar, Swift, Amy J, Kuusisto, Johanna, Bergman, Richard N, Sundvall, Jouko, Laakso, Markku, Ferrucci, Luigi, Scheet, Paul, Sanna, Serena, Uda, Manuela, Yang, Qiong, Lunetta, Kathryn, Dupuis, Josee, deBakker, Paul I, O’Donnell, Christopher J, Chambers, John C, Kooner, Jaspal S, Hercberg, Serge, Meneton, Pierre, Lakatta, Edward G, Scuteri, Angelo, Schlessinger, David, Tuomilehto, Jaakko, Collins, Francis S, Groop, Leif, Altshuler, David, Collins, Rory, Lathrop, G Mark, Melander, Olle, Salomaa, Veikko, Peltonen, Leena, Orho-Melander, Marju, Ordovas, Jose M, Boehnke, Michael, Abecasis, Gonçalo R, Mohlke, Karen L, Cupples, L Adrienne
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2881676/
https://ncbi.nlm.nih.gov/pubmed/19060906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.291
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