Structures of PHR domains from Mus musculus Phr1 (Mycbp2) explain the loss of function mutation (Gly1092→Glu) of the C. elegans ortholog RPM-1

PHR (Pam-Highwire-RPM-1) proteins are conserved, large multi-domain E3 ubiquitin ligases with modular architecture. PHR proteins presynaptically control synaptic growth and axon guidance and postsynaptically regulate endocytosis of glutamate receptors. Dysfunction of neuronal ubiquitin-mediated prot...

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Bibliografiske detaljer
Main Authors: Sampathkumar, Parthasarathy, Ozyurt, Sinem A., Miller, Stacy, Bain, Kevin T., Rutter, Marc E., Gheyi, Tarun, Abrams, Benjamin, Wang, Yingchun, Atwell, Shane, Luz, John G., Thompson, Devon A., Wasserman, Stephen R., Spencer Emtage, J., Park, Eunchan C., Rongo, Christopher, Jin, Yishi, Klemke, Richard L., Michael Sauder, J., Burley, Stephen K.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2881670/
https://ncbi.nlm.nih.gov/pubmed/20156452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.02.017
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