A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers

In a genome-wide screen of 684 cancer cell lines, we identified homozygous intragenic microdeletions involving genes encoding components of the apical-basal cell polarity complexes. Among these, PARD3 is disrupted in cell lines and primary tumors from squamous carcinomas and glioblastomas. Reconstit...

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Detalhes bibliográficos
Main Authors: Rothenberg, S. Michael, Mohapatra, Gayatry, Rivera, Miguel N., Winokur, Daniel, Greninger, Patricia, Nitta, Mai, Sadow, Peter M., Sooriyakumar, Gaya, Brannigan, Brian W., Ulman, Matthew J., Perera, Rushika M., Wang, Rui, Tam, Angela, Ma, Xiao-Jun, Erlander, Mark, Sgroi, Dennis C., Rocco, James W., Lingen, Mark W., Cohen, Ezra E.W., Louis, David N., Settleman, Jeffrey, Haber, Daniel A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2881662/
https://ncbi.nlm.nih.gov/pubmed/20215515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-3458
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