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Eosinophil cationic granule proteins impair thrombomodulin function. A potential mechanism for thromboembolism in hypereosinophilic heart disease.

Thromboembolism is a prominent but poorly understood feature of eosinophilic, or Loeffler's endocarditis. Eosinophil (EO) specific granule proteins, in particular major basic protein (MBP), accumulate on endocardial surfaces in the course of this disease. We hypothesized that these unusually cationi...

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Detalles Bibliográficos
Publicado en:J Clin Invest
Principais autores: Slungaard, A, Vercellotti, G M, Tran, T, Gleich, G J, Key, N S
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 1993
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC288152/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8386194/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116382
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