Eosinophil cationic granule proteins impair thrombomodulin function. A potential mechanism for thromboembolism in hypereosinophilic heart disease.

Thromboembolism is a prominent but poorly understood feature of eosinophilic, or Loeffler's endocarditis. Eosinophil (EO) specific granule proteins, in particular major basic protein (MBP), accumulate on endocardial surfaces in the course of this disease. We hypothesized that these unusually cationi...

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Publicado en:	J Clin Invest
Autores principales:	Slungaard, A, Vercellotti, G M, Tran, T, Gleich, G J, Key, N S
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Clinical Investigation 1993
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC288152/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8386194/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116382
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