Eosinophil cationic granule proteins impair thrombomodulin function. A potential mechanism for thromboembolism in hypereosinophilic heart disease.

Thromboembolism is a prominent but poorly understood feature of eosinophilic, or Loeffler's endocarditis. Eosinophil (EO) specific granule proteins, in particular major basic protein (MBP), accumulate on endocardial surfaces in the course of this disease. We hypothesized that these unusually cationi...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Slungaard, A, Vercellotti, G M, Tran, T, Gleich, G J, Key, N S
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC288152/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8386194/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116382
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