Eosinophil cationic granule proteins impair thrombomodulin function. A potential mechanism for thromboembolism in hypereosinophilic heart disease.

Thromboembolism is a prominent but poorly understood feature of eosinophilic, or Loeffler's endocarditis. Eosinophil (EO) specific granule proteins, in particular major basic protein (MBP), accumulate on endocardial surfaces in the course of this disease. We hypothesized that these unusually cationi...

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Pubblicato in:	J Clin Invest
Autori principali:	Slungaard, A, Vercellotti, G M, Tran, T, Gleich, G J, Key, N S
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1993
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC288152/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8386194/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116382
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