Doxorubicin cardiomyopathy is associated with a decrease in calcium release channel of the sarcoplasmic reticulum in a chronic rabbit model.

Doxorubicin is a highly effective cancer chemotherapeutic agent that produces a dose-dependent cardiomyopathy that limits its clinical usefulness. Clinical and animal studies of morphological changes during the early stages of doxorubicin-induced cardiomyopathy have suggested that the sarcoplasmic r...

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Bibliographic Details
Main Authors: Dodd, D A, Atkinson, J B, Olson, R D, Buck, S, Cusack, B J, Fleischer, S, Boucek, R J
Format: Artigo
Language:Inglês
Published: 1993
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC288149/
https://ncbi.nlm.nih.gov/pubmed/8386192
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