Doxorubicin cardiomyopathy is associated with a decrease in calcium release channel of the sarcoplasmic reticulum in a chronic rabbit model.

Doxorubicin is a highly effective cancer chemotherapeutic agent that produces a dose-dependent cardiomyopathy that limits its clinical usefulness. Clinical and animal studies of morphological changes during the early stages of doxorubicin-induced cardiomyopathy have suggested that the sarcoplasmic r...

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Veröffentlicht in:	J Clin Invest
Hauptverfasser:	Dodd, D A, Atkinson, J B, Olson, R D, Buck, S, Cusack, B J, Fleischer, S, Boucek, R J
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical Investigation 1993
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC288149/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8386192/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116379
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