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Negative transcriptional regulation of human interleukin 2 (IL-2) gene by glucocorticoids through interference with nuclear transcription factors AP-1 and NF-AT.

IL-2 gene transcription is affected by several nuclear proteins. We asked whether dexamethasone (Dex) and cyclosporin A (CsA) inhibit IL-2 gene transcription by interfering with the activity of nuclear proteins that bind to the IL-2 promoter. Nuclear extracts from primary human T lymphocytes were an...

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Bibliografische gegevens
Hoofdauteurs: Paliogianni, F, Raptis, A, Ahuja, S S, Najjar, S M, Boumpas, D T
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 1993
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC288123/
https://ncbi.nlm.nih.gov/pubmed/8473495
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