Negative transcriptional regulation of human interleukin 2 (IL-2) gene by glucocorticoids through interference with nuclear transcription factors AP-1 and NF-AT.

IL-2 gene transcription is affected by several nuclear proteins. We asked whether dexamethasone (Dex) and cyclosporin A (CsA) inhibit IL-2 gene transcription by interfering with the activity of nuclear proteins that bind to the IL-2 promoter. Nuclear extracts from primary human T lymphocytes were an...

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Pubblicato in:	J Clin Invest
Autori principali:	Paliogianni, F, Raptis, A, Ahuja, S S, Najjar, S M, Boumpas, D T
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1993
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC288123/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8473495/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116353
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