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Conformational dynamics of single pre–mRNA molecules during in vitro splicing
The spliceosome is a complex small nuclear (sn)RNA–protein machine that removes introns from pre–mRNAs via two successive phosphoryl transfer reactions. The chemical steps are isoenergetic, yet splicing requires at least eight RNA–dependent ATPases responsible for substantial conformational rearrang...
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| Hoofdauteurs: | , , , , , , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2010
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2881217/ https://ncbi.nlm.nih.gov/pubmed/20305654 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1767 |
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