Conformational dynamics of single pre–mRNA molecules during in vitro splicing

The spliceosome is a complex small nuclear (sn)RNA–protein machine that removes introns from pre–mRNAs via two successive phosphoryl transfer reactions. The chemical steps are isoenergetic, yet splicing requires at least eight RNA–dependent ATPases responsible for substantial conformational rearrang...

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Main Authors: Abelson, John, Blanco, Mario, Ditzler, Mark A., Fuller, Franklin, Aravamudhan, Pavithra, Wood, Mona, Villa, Tommaso, Ryan, Daniel E., Pleiss, Jeffrey A., Maeder, Corina, Guthrie, Christine, Walter, Nils G.
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2881217/
https://ncbi.nlm.nih.gov/pubmed/20305654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1767
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