A new antiinflammatory compound, leumedin, inhibits modification of low density lipoprotein and the resulting monocyte transmigration into the subendothelial space of cocultures of human aortic wall cells.

Addition of leumedin, N-[9H-(2,7-dimethylfluorenyl-9-methoxy) carbon]-L-leucine at 30-60 microM together with LDL almost completely prevented the induction of monocyte chemotactic protein mRNA, reduced monocyte chemotactic protein 1 levels by 84%, and inhibited monocyte migration into the subendothe...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Navab, M, Hama, S Y, Van Lenten, B J, Drinkwater, D C, Laks, H, Fogelman, A M
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC288081/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8450051/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116284
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