A Genetic Switch to Hypervirulence Reduces Colonization Phenotypes of the Globally Disseminated Group A Streptococcus M1T1 Clone

BACKGROUND: The recent resurgence of invasive group A streptococcal disease has been paralleled by the emergence of the M1T1 clone. Recently, invasive disease initiation to has been linked to mutations in the covR/S two-compnent regulator. Here we investigate if a fitness cost is associated with cov...

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Hauptverfasser: Hollands, Andrew, Pence, Morgan A., Timmer, Anjuli M., Osvath, Sarah R., Turnbull, Lynne, Whitchurch, Cynthia B., Walker, Mark J., Nizet, Victor
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2880657/
https://ncbi.nlm.nih.gov/pubmed/20507231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1086/653124
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