Streptococcal Inhibitor of Complement Promotes Innate Immune Resistance Phenotypes of Invasive M1T1 Group A Streptococcus

Streptococcal inhibitor of complement (SIC) is a highly polymorphic extracellular protein and putative virulence factor secreted by M1 and M57 strains of group A Streptococcus (GAS). The sic gene is highly upregulated in invasive M1T1 GAS isolates following selection of mutations in the covR/S regul...

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Autori principali: Pence, Morgan A., Rooijakkers, Suzan H.M., Cogen, Anna L., Cole, Jason N., Hollands, Andrew, Gallo, Richard L., Nizet, Victor
Natura: Artigo
Lingua:Inglês
Pubblicazione: S. Karger AG 2010
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3219503/
https://ncbi.nlm.nih.gov/pubmed/20814187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000317672
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