Streptolysin O Promotes Group A Streptococcus Immune Evasion by Accelerated Macrophage Apoptosis

Group A Streptococcus (GAS) is a leading human bacterial pathogen capable of producing invasive infections even in previously healthy individuals. As frontline components of host innate defense, macrophages play a key role in control and clearance of GAS infections. We find GAS induces rapid, dose-d...

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Detalhes bibliográficos
Main Authors: Timmer, Anjuli M., Timmer, John C., Pence, Morgan A., Hsu, Li-Chung, Ghochani, Mariam, Frey, Terrence G., Karin, Michael, Salvesen, Guy S., Nizet, Victor
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2613605/
https://ncbi.nlm.nih.gov/pubmed/19001420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804632200
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