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Transgenic mice expressing a partially deleted gene for type I procollagen (COL1A1). A breeding line with a phenotype of spontaneous fractures and decreased bone collagen and mineral.

A line of transgenic mice was prepared that expressed moderate levels of an internally deleted human gene for the pro alpha 1(I) chain of type I procollagen. The gene construct was modeled after a sporadic in-frame deletion of the human gene that produced a lethal variant of osteogenesis imperfecta...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Pereira, R, Khillan, J S, Helminen, H J, Hume, E L, Prockop, D J
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 1993
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC288013/
https://ncbi.nlm.nih.gov/pubmed/8432871
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