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Mutational fitness effects in RNA and single-stranded DNA viruses: common patterns revealed by site-directed mutagenesis studies
The fitness effects of mutations are central to evolution, yet have begun to be characterized in detail only recently. Site-directed mutagenesis is a powerful tool for achieving this goal, which is particularly suited for viruses because of their small genomes. Here, I discuss the evolutionary relev...
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| Formato: | Artigo |
| Idioma: | Inglês |
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The Royal Society
2010
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2880115/ https://ncbi.nlm.nih.gov/pubmed/20478892 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rstb.2010.0063 |
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