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Nucleoside Analogue Mutagenesis of a Single-Stranded DNA Virus: Evolution and Resistance

It has been well established that chemical mutagenesis has adverse fitness effects in RNA viruses, often leading to population extinction. This is mainly a consequence of the high RNA virus spontaneous mutation rates, which situate them close to the extinction threshold. Single-stranded DNA viruses...

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Bibliographic Details
Main Authors: Domingo-Calap, Pilar, Pereira-Gómez, Marianoel, Sanjuán, Rafael
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2012
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3446564/
https://ncbi.nlm.nih.gov/pubmed/22740415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00613-12
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