Lack of HLA class I antigen expression by melanoma cells SK-MEL-33 caused by a reading frameshift in beta 2-microglobulin messenger RNA.

The lack of HLA class I antigen expression by the melanoma cell line SK-MEL-33 is caused by a unique lesion in beta 2-microglobulin (beta 2-mu). Sequencing of beta 2-mu mRNA detected a guanosine deletion at position 323 in codon 76 that causes a frameshift with a subsequent introduction of a stop co...

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Publicat a:J Clin Invest
Autors principals: Wang, Z, Cao, Y, Albino, A P, Zeff, R A, Houghton, A, Ferrone, S
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 1993
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC288010/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8432869/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116249
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