Genetic deficiency of Irgm1 (LRG-47) suppresses induction of experimental autoimmune encephalomyelitis by promoting apoptosis of activated CD4(+) T cells

The immunity-related GTPase Irgm1, also called LRG-47, is known to regulate host resistance to intracellular pathogens through multiple mechanisms that include controlling the survival of T lymphocytes. Here, we address whether Irgm1 also plays a role in the pathogenesis of experimental autoimmune e...

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Hauptverfasser: Xu, Hongwei, Wu, Zhi-Ying, Fang, Fang, Guo, Lan, Chen, Doris, Chen, John Xi, Stern, David, Taylor, Gregory A., Jiang, Hong, Yan, Shirley ShiDu
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Federation of American Societies for Experimental Biology 2010
Schlagworte:
Research Communications
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2879948/
https://ncbi.nlm.nih.gov/pubmed/20056715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.09-137323
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