Prediction of breast cancer sensitivity to neoadjuvant chemotherapy based on status of DNA damage repair proteins

INTRODUCTION: Various agents used in breast cancer chemotherapy provoke DNA double-strand breaks (DSBs). DSB repair competence determines the sensitivity of cells to these agents whereby aberrations in the repair machinery leads to apoptosis. Proteins required for this pathway can be detected as nuc...

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Autores principales: Asakawa, Hideki, Koizumi, Hirotaka, Koike, Ayaka, Takahashi, Makiko, Wu, Wenwen, Iwase, Hirotaka, Fukuda, Mamoru, Ohta, Tomohiko
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2010
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Research article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2879561/
https://ncbi.nlm.nih.gov/pubmed/20205718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr2486
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