Prediction of breast cancer sensitivity to neoadjuvant chemotherapy based on status of DNA damage repair proteins

INTRODUCTION: Various agents used in breast cancer chemotherapy provoke DNA double-strand breaks (DSBs). DSB repair competence determines the sensitivity of cells to these agents whereby aberrations in the repair machinery leads to apoptosis. Proteins required for this pathway can be detected as nuc...

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Main Authors: Asakawa, Hideki, Koizumi, Hirotaka, Koike, Ayaka, Takahashi, Makiko, Wu, Wenwen, Iwase, Hirotaka, Fukuda, Mamoru, Ohta, Tomohiko
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2010
Fag:
Research article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2879561/
https://ncbi.nlm.nih.gov/pubmed/20205718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr2486
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