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Exaggerated emotional behavior in mice heterozygous for the sodium channel Scn8a (Na(v)1.6)

The SCN8A gene encodes the α-subunit of Na(v)1.6, a neuronal voltage-gated sodium channel. Mice homozygous for mutations in the Scn8a gene exhibit motor impairments. Recently a human family with a heterozygous protein truncation mutation in SCN8A has been described. Rather than motor impairment, neu...

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Bibliografiske detaljer
Main Authors: McKinney, Brandon C., Chow, Clement Y., Meisler, Miriam H., Murphy, Geoffrey G.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2879430/
https://ncbi.nlm.nih.gov/pubmed/18363861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1601-183X.2008.00399.x
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