Stimuli of Sensory-Motor Nerves Terminate Arterial Contractile Effects of Endothelin-1 by CGRP and Dissociation of ET-1/ET(A)-Receptor Complexes

BACKGROUND: Endothelin-1 (ET-1), a long-acting paracrine mediator, is implicated in cardiovascular diseases but clinical trials with ET-receptor antagonists were not successful in some areas. We tested whether the quasi-irreversible receptor-binding of ET-1 (i) limits reversing effects of the antago...

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Main Authors: Meens, Merlijn J. P. M. T., Compeer, Matthijs G., Hackeng, Tilman M., van Zandvoort, Marc A., Janssen, Ben J. A., De Mey, Jo G. R.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2010
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2879375/
https://ncbi.nlm.nih.gov/pubmed/20532232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010917
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