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Primary granule exocytosis in human neutrophils is regulated by Rac-dependent actin remodeling

The actin cytoskeleton regulates exocytosis in all secretory cells. In neutrophils, Rac2 GTPase has been shown to control primary (azurophilic) granule exocytosis. Here, we propose that Rac2 is required for actin cytoskeletal remodeling to promote primary granule exocytosis. Treatment of neutrophils...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Mitchell, Troy, Lo, Andrea, Logan, Mike, Lacy, Paige, Eitzen, Gary
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2878813/
https://ncbi.nlm.nih.gov/pubmed/18799653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00239.2008
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