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Determinants of Sequence-Specificity within Human AID and APOBEC3G

Human APOBEC3G (A3G) and activation-induced deaminase (AID) belong to a family of DNA-cytosine deaminases. While A3G targets the last C in a run of C’s, AID targets C in the consensus sequence WRC (W is A or T and R is a purine). Guided by the structures of the A3G carboxyl-terminal catalytic domain...

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Autors principals: Carpenter, Michael A., Rajagurubandara, Erandi, Wijesinghe, Priyanga, Bhagwat, Ashok S.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2878719/
https://ncbi.nlm.nih.gov/pubmed/20338830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2010.02.010
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