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Determinants of Sequence-Specificity within Human AID and APOBEC3G
Human APOBEC3G (A3G) and activation-induced deaminase (AID) belong to a family of DNA-cytosine deaminases. While A3G targets the last C in a run of C’s, AID targets C in the consensus sequence WRC (W is A or T and R is a purine). Guided by the structures of the A3G carboxyl-terminal catalytic domain...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2878719/ https://ncbi.nlm.nih.gov/pubmed/20338830 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2010.02.010 |
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