Tumor Necrosis Factor (TNF) Signaling, but Not TWEAK (TNF-like Weak Inducer of Apoptosis)-triggered cIAP1 (Cellular Inhibitor of Apoptosis Protein 1) Degradation, Requires cIAP1 RING Dimerization and E2 Binding

Cellular inhibitor of apoptosis (cIAP) proteins, cIAP1 and cIAP2, are important regulators of tumor necrosis factor (TNF) superfamily (SF) signaling and are amplified in a number of tumor types. They are targeted by IAP antagonist compounds that are undergoing clinical trials. IAP antagonist compoun...

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Bibliographische Detailangaben
Hauptverfasser: Feltham, Rebecca, Moulin, Maryline, Vince, James E., Mace, Peter D., Wong, Wendy Wei-Lynn, Anderton, Holly, Day, Catherine L., Vaux, David L., Silke, John
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2010
Schlagworte:
Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2878517/
https://ncbi.nlm.nih.gov/pubmed/20356846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.087635
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