Cbl-b Is a Novel Physiologic Regulator of Glycoprotein VI-dependent Platelet Activation

Cbl-b, a member of the Cbl family of E3 ubiquitin ligases, plays an important role in the activation of lymphocytes. However, its function in platelets remains unknown. We show that Cbl-b is expressed in human platelets along with c-Cbl, but in contrast to c-Cbl, it is not tyrosine-phosphorylated up...

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Autori principali: Daniel, James L., Dangelmaier, Carol A., Mada, Sripal, Buitrago, Lorena, Jin, Jianguo, Langdon, Wallace Y., Tsygankov, Alexander Y., Kunapuli, Satya P., Sanjay, Archana
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2010
Soggetti:
Signal Transduction
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2878491/
https://ncbi.nlm.nih.gov/pubmed/20400514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.080200
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