LVIS553 Transcriptional Regulator Specifically Recognizes Novobiocin as an Effector Molecule

In this study we aimed to identify small molecules with high affinity involved in the allosteric regulation of LVIS553, a MarR member from Lactobacillus brevis ATCC367. Using high throughput screening, novobiocin was found to specifically bind LVIS553 with a K(D) = 33.8 ± 2.9 μm consistent with a bi...

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Bibliographic Details
Main Authors: Pagliai, Fernando A., Gardner, Christopher L., Pande, Santosh G., Lorca, Graciela L.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2878039/
https://ncbi.nlm.nih.gov/pubmed/20308066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.111138
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