Dysfunction of the Scn8a Voltage-gated Sodium Channel Alters Sleep Architecture, Reduces Diurnal Corticosterone Levels, and Enhances Spatial Memory

Voltage-gated sodium channels (VGSCs) are responsible for the initiation and propagation of transient depolarizing currents and play a critical role in the electrical signaling between neurons. A null mutation in the VGSC gene SCN8A, which encodes the transmembrane protein Na(v)1.6, was identified p...

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Main Authors: Papale, Ligia A., Paul, Ketema N., Sawyer, Nikki T., Manns, Joseph R., Tufik, Sergio, Escayg, Andrew
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Neurobiology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2878034/
https://ncbi.nlm.nih.gov/pubmed/20353942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.090084
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