α-AP-2 Directs Myosin VI-dependent Endocytosis of Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channels in the Intestine

The actin motor myosin VI regulates endocytosis of cystic fibrosis transmembrane conductance regulator (CFTR) in the intestine, but the endocytic adaptor linking CFTR to myosin VI is unknown. Dab2 (Disabled 2) is the binding partner for myosin VI, clathrin, and α-AP-2 and directs endocytosis of low...

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Autores principales: Collaco, Anne, Jakab, Robert, Hegan, Peter, Mooseker, Mark, Ameen, Nadia
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Materias:
Cell Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2878018/
https://ncbi.nlm.nih.gov/pubmed/20351096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.127613
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