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The G(q)/G(11)-mediated signaling pathway is critical for autocrine potentiation of insulin secretion in mice
A variety of neurotransmitters, gastrointestinal hormones, and metabolic signals are known to potentiate insulin secretion through GPCRs. We show here that β cell–specific inactivation of the genes encoding the G protein α-subunits Gα(q) and Gα(11) resulted in impaired glucose tolerance and insulin...
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| Asıl Yazarlar: | , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
American Society for Clinical Investigation
2010
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2877950/ https://ncbi.nlm.nih.gov/pubmed/20440069 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI41541 |
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