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Thyrocyte-specific G(q)/G(11) deficiency impairs thyroid function and prevents goiter development

The function of the adult thyroid is regulated by thyroid-stimulating hormone (TSH), which acts through a G protein–coupled receptor. Overactivation of the TSH receptor results in hyperthyroidism and goiter. The G(s)-mediated stimulation of adenylyl cyclase–dependent cAMP formation has been regarded...

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Bibliografiske detaljer
Main Authors: Kero, Jukka, Ahmed, Kashan, Wettschureck, Nina, Tunaru, Sorin, Wintermantel, Tim, Greiner, Erich, Schütz, Günther, Offermanns, Stefan
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1937498/
https://ncbi.nlm.nih.gov/pubmed/17694176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI30380
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