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Thyrocyte-specific G(q)/G(11) deficiency impairs thyroid function and prevents goiter development
The function of the adult thyroid is regulated by thyroid-stimulating hormone (TSH), which acts through a G protein–coupled receptor. Overactivation of the TSH receptor results in hyperthyroidism and goiter. The G(s)-mediated stimulation of adenylyl cyclase–dependent cAMP formation has been regarded...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Clinical Investigation
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1937498/ https://ncbi.nlm.nih.gov/pubmed/17694176 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI30380 |
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